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Poolbeg Pharma's POLB 001 immuno-modulator II receives fully-granted patent from US Patent Office

Poolbeg Pharma PLC

Poolbeg Pharma PLC (AIM:POLB, OTCQB:POLBF) chief legal officer John McEvoy joins Proactive's Stephen Gunnion with news that POLB 001's Immuno-modulator II has received the fully granted patent from the US Patent Office. McEvoy explained the patent encompasses a class of drugs for treating and preventing hypercytokinemia (cytokine storms) in patients triggered by an immune response, applicable across multiple disease indications. The granted patent further solidifies Poolbeg Pharma's robust intellectual property portfolio for POLB 001, potentially increasing the asset's value and making it more attractive to potential partners. McEvoy highlighted the company's ongoing efforts to strengthen and expand their IP portfolio, noting existing patents covering p38 MAP kinase inhibitors for influenza treatment and hypercytokinemia. Additional patents have been filed, particularly focusing on cancer immunotherapy applications of POLB 001. The company has also applied for patents concerning dosage regimens based on results from their recent LPs trial, aiming to protect innovations and maintain a competitive edge in the pharmaceutical market. This strategic IP protection is crucial for safeguarding the company's products and ensuring shareholder value, particularly as they seek partnerships to further develop POLB 001. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

May 08, 2024 08:32 AM Eastern Daylight Time

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Electric Guitar debuts on AIM with big plans following 3radical acquisition

Electric Guitar PLC

Electric Guitar PLC (AIM:ELEG) CEO John Regan spoke to Proactive's Stephen Gunnion following the company's listing on London's AIM market following the reverse takeover of 3radical. Regan emphasized Electric Guitar's "buy and build" strategy, which involves acquiring complementary businesses to enhance their market position. Despite the challenging market conditions, the company managed to complete its IPO on AIM, a testament to its team's strength and compelling business proposition. 3radical specialises in collecting first-party data—a valuable asset in today's privacy-focused advertising market. This acquisition marks Electric Guitar's entry into the technical side of the advertising industry, responding to significant shifts such as reduced accessibility to third-party data due to privacy regulations. 3radical's technology allows for real-time adaptation to user input, which is unique in the market and enhances the relevancy of advertising. Furthermore, Regan said 3radical's extensive database of engagement events offers potential for advanced machine learning applications, positioning Electric Guitar to exploit AI technologies effectively. Looking forward, Regan outlined plans to enhance sales and marketing efforts, particularly focusing on exploiting the newly acquired technologies and data assets from 3radical. Electric Guitar is also preparing to expand its portfolio by acquiring additional complementary businesses, aiming to leverage these new assets to secure a competitive advantage in a rapidly evolving market. Contact Details Proactive UK +44 20 7989 0813 UKEditorial@proactiveinvestors.com

May 08, 2024 08:24 AM Eastern Daylight Time

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Faron Pharmaceuticals' new CEO Dr Juho Jalkanen sets bold vision for 2024

Faron Pharmaceuticals Oy

Faron Pharmaceuticals Limited (AIM:FARN) new CEO Dr Juho Jalkanen joined Proactive's Stephen Gunnion with his vision for the company. The founding member and former chief operating officer of Faron said one of his priorities is to meet with the US Food & Drug Administration earlier than planned in the hope of fast-tracking its lead drug, bexmarilimab, which has shown huge promise in treating a type of rare blood cancer. The move follows promising data from the phase I trials involving patients with myelodysplastic syndrome (MDS) who were unresponsive to a class of drugs called hypomethylating agents (HMAs). Jalkanen highlighted the company's ongoing phase 2 trial targeting relapsed refractory MDS, emphasising the strategic goal of securing non-dilutive funding and considering future mergers and acquisitions as the drug shows promise. Jalkanen also discussed the potential of the lead drug candidate in treating specific macrophage-driven cancers, indicating an optimistic outlook for the near term, including significant milestones expected in 2024. These milestones include more phase 2 data, expected by late May, and subsequent FDA feedback, pivotal for future planning. The CEO expressed confidence in the company's position and its appeal to investors, especially given the biotech sector's recovery from a period he referred to as a "nuclear winter." Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

May 08, 2024 08:19 AM Eastern Daylight Time

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Iofina's strategic success: revenue surpasses $50 million, expansion underway

Iofina PLC

Iofina PLC (AIM:IOF, OTC:IOFNF) CEO Dr Tom Becker takes Proactive's Stephen Gunnion through the company's 2023 full-year performance, which marked another record. Iofina achieved its first-ever revenue exceeding $50 million, marking the sixth consecutive year of growth, a roughly 18% increase from the previous year, with EBITDA at $10.8 million. Becker attributed the growth to effective company strategies but noted challenges like increased input costs due to rising prices of chemicals used in their iodine extraction processes. He anticipates these costs will not escalate as sharply moving forward. Despite a slightly lower realised iodine price in 2023 compared to 2022, the market remains strong, particularly driven by demand for X-ray contrast media. Becker expects iodine prices to remain high, projecting stability into 2024. Iofina also reported strong cash generation, enabling significant debt reduction and a net cash position of $1.2 million. This financial health supports their ongoing investments in expanding iodine production, with new plants such as IO#9 operational and IO#10 expected to start in Q3 2024. Future expansions include plans for an IO#11 plant. Becker highlighted the seasonal increase in iodine production, with the second quarter typically seeing more output due to favourable conditions, and projected an overall increase in 2024 production. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

May 08, 2024 08:16 AM Eastern Daylight Time

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ANGLE announces second assay with AstraZeneca as it deepens relationship with pharma giant

ANGLE PLC

ANGLE PLC chief executive Andrew Newland joins Proactive's Stephen Gunnion with details of a supplier agreement with AstraZeneca PLC to develop an androgen receptor (AR) detection assay to enhance prostate cancer studies. With a contract value of £550,000, the project is scheduled for completion in the first quarter of next year. Newland said the agreement is an extension of a prior arrangement to develop a methodology for detecting CTC micronuclei and will use ANGLE's innovative Parsortix system. Successful development of this AR assay is expected to bolster the use of the Parsortix system in clinical oncology, particularly for assessing the efficacy of prostate cancer therapies. The discussion also touched upon the potential benefits of this development for ANGLE, suggesting it might significantly enhance the company's operations and market position. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

May 08, 2024 08:12 AM Eastern Daylight Time

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Team Internet CEO Michael Riedl discusses growth and integration post-Shinez acquisition

Team Internet Group PLC

Team Internet Group PLC (AIM:TIG, OTCQX:TIGXF) CEO Michael Riedl discusses the completion of the acquisition of Shinez, a digital content production and promotion company specialising in listicle-based articles with embedded advertisements. Riedl noted that the acquisition is immediately accretive to earnings, with an expected high single-digit EPS accretion for the year, even before accounting for synergies. He highlighted that Shinez attracts different customer groups early in the decision-making process, which complements Team Internet's existing product suite. With the inclusion of Shinez, Team Internet now covers the entire marketing conversion funnel, from initial awareness to final sale conversions, he added. Riedl also discussed future growth strategies, emphasizing the enhanced capability to target consumers at every stage of their decision-making journey, thus increasing shareholder value. He mentioned leveraging synergies such as cross-promoting products and integrating ad inventories. The acquisition strengthens Team Internet's relationship with significant internet players like Meta, providing potential spillover benefits. Looking ahead, Team Internet plans to deepen its involvement in social media and expand its network of demand-side partners to better tailor commercial offers to consumers. Contact Details Proactive UK +44 20 7989 0813 UKEditorial@proactiveinvestors.com

May 08, 2024 08:06 AM Eastern Daylight Time

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HIVE Digital Technologies CEO Aydin Kilic discusses strategic growth in AI and crypto mining

HIVE Digital Technologies

HIVE Digital Technologies (TSX-V:HIVE, NASDAQ:HIVE) president and CEO Aydin Kilic joined Stephen Gunnion in Proactive's London studio with insights into the company’s transition and growth. Initially established as the first publicly traded crypto mining company in 2017, HIVE began by mining Ethereum in Iceland before expanding to Sweden and Canada. Following Ethereum's transition during the merge, HIVE pivoted its GPU resources from Ethereum to Bitcoin mining and later to AI computing. This strategic shift has proven profitable, with the AI computing segment achieving a $1 million annual run rate in its initial beta test phase and growing to an almost $10 million Internal Rate of Return (IRR) in the subsequent year. Kilic also discussed the operational differences between the company's rugged crypto mining facilities and its refined, high-performance tier-three data centers, located strategically to leverage green energy sources like hydropower and geothermal energy. These centers are distinct in their operations, focusing either on AI computing or Bitcoin mining, each with substantial revenue potential. Moreover, Hive manages to keep a balanced approach by maintaining efficiency in Bitcoin operations, leveraging market cycles to optimize investment and profit from fluctuations in Bitcoin prices. Kilic highlighted the company’s financial health, noting its significant Bitcoin treasury and minimal debt, providing stability amidst market volatility. Looking ahead, Hive aims to expand its AI revenue significantly, with ambitious targets set for the upcoming quarters, further solidifying its dual approach to leveraging both AI and Bitcoin mining for growth and investor value. Contact Details Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

May 08, 2024 08:03 AM Eastern Daylight Time

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Axmed raises $2 million to transform access to critical medicines in low and middle income countries

Axmed

For too long, low- and middle-income countries (LMICs) have borne the brunt of global health disparities—accounting for over 80% of the world's population and more than 90% of its disease burden—yet representing a mere 6% of global pharmaceutical revenue. Equitable access to high quality affordable medicines remains a daunting task, and addressing this challenge has never been more critical. Axmed, an innovative two-sided B2B marketplace platform, is taking a bold and meaningful step forward in addressing this disparity with the announcement of a $2 million seed funding round. This investment aims to accelerate the affordability, availability, and distribution of essential and innovative medicines in underserved regions. The fresh investment was led by Founderful and complements an earlier $5 million in grant funding from the Bill and Melinda Gates Foundation, bringing total funds raised to $7 million. These funds will bolster Axmed's expansion, enhancing its engineering and commercial teams and advancing its technology infrastructure to initiate operations in strategically selected markets within Africa and the Caribbean. Axmed's B2B marketplace optimises the procurement process for healthcare providers in emerging and growth markets, catering to public, third sector, and private entities. The platform aggregates demand for both off-patent and patented medicines, creating larger, more cost-effective order volumes for manufacturers while simultaneously enhancing buyer leverage on cost and availability. The platform further streamlines the process by curating and consolidating Requests for Proposals and efficiently mapping out supply logistics. This approach creates a win-win outcome: it lowers the barriers to accessing costly medicines for patients and providers, while enabling manufacturers to expand their footprint in underserved markets. Axmed's founding team brings together a wealth of expertise and dedication, with over 30 years of collective experience in healthcare, finance, and public-private partnerships. CEO Emmanuel Akpakwu, previously Chief Commercial Officer for Novartis AG's Sub-Saharan Africa operations, is joined by Felix Ohnmacht and Sofia Radley-Searle, who have held key positions at Novartis and GSK, respectively. Their united vision is to tackle healthcare inequity head-on. Emmanuel Akpakwu, CEO of Axmed commented: "We are not merely developing a medicines platform; we are creating a bold new vision for the future of medicine accessibility. This vision not only empowers buyers but also unlocks the full potential of growth markets, allowing suppliers to compete effectively.” This seed round propels Axmed into its next phase of strategic expansion, driving significant advancements in building out the engineering and business development teams, whilst preparing the platform for launch. Through targeted deployment of funds, Axmed will enhance its marketplace technology and forge alliances with key healthcare stakeholders to ensure a reliable supply of critical medicines. "We're delighted to back this outstanding team," added Lukas Weder, Founding Partner at Founderful. "The team's commitment and enthusiasm for addressing this important challenge is inspiring. We have every confidence in their ability to reshape the $140 billion LMIC pharma market, improving access to medicines for over 6 billion individuals. " Axmed's mission extends beyond technology; it's about forging critical partnerships and ensuring a steady flow of crucial medicines to those in need. Despite LMICs' small share of the global pharmaceutical market, they represent a burgeoning $140 billion sector, with Africa alone accounting for over $43 billion in pharmaceutical opportunity. The urgency for accessible and affordable healthcare solutions has never been more evident, especially in the wake of the COVID-19 pandemic, which highlighted the need for a coordinated and sustainable medicines marketplace tailored to LMICs. "Industry leaders and healthcare providers are aligned in their support for Axmed's model, recognizing its potential to significantly enhance medicine accessibility in Low and Middle-Income Countries. "Axmed's approach could fundamentally change how patients obtain treatments," remarked Roselyne Opel, Head of the Organisation of Eastern Caribbean States Pooled Procurement Initiative (OECS PPI). "We look forward to seeing their platform reshape access, empowering buyers and strengthening supply of lifesaving therapies to a broader patient base." James Nyamongo, CEO of the Nairobi Hospital, Kenya added: “Axmed’s approach not only empowers us to gain access to life-saving medicines affordably, it also fosters real competition that raises the quality bar, bringing the highest quality local and global manufacturers to our doorstep”. Thibaud Lefort, Head of Operations for Sanofi’s Global Health Unit, added: "Axmed’s model presents a powerful opportunity to deliver much needed positive change across global health. We are eager to see their platform transform the access landscape, improving supplier-ability to reach more patients with lifesaving therapies, especially in underserved environments” As the deadline for the UN Sustainable Development Goals approaches, Emmanuel Akpakwu reaffirms Axmed's commitment: "We are driven by the belief that radical solutions are necessary to build on the progress being made across the various facets of global health. Axmed represents such a solution, and we are eager to make a positive, lasting impact on the world." About Axmed Axmed is an innovative healthcare venture focused on transforming access to medicines across low- and middle-income countries (LMICs). Through its robust digital platform, Axmed operates a two-sided B2B marketplace that bridges the gap between pharmaceutical manufacturers/suppliers and healthcare providers, ensuring a steady, affordable supply of critical medicines. By leveraging technology, strategic partnerships, and a deep understanding of the unique challenges faced by LMICs, Axmed is committed to fostering sustainable health outcomes and accelerating global health equity. About Founderful Founderful is Switzerland’s leading pre-seed fund. We give every founder our deepest understanding and highest levels of support, and together, we’re building the future of the Swiss startup ecosystem. Contact Details Axmed Bilal Mahmood +44 7714 007257 b.mahmood@stockwoodstrategy.com Company Website https://www.axmed.com/

May 08, 2024 08:00 AM Eastern Daylight Time

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PRESTIGEPEO WINS TWO STEVIE® AWARDS IN 2024 AMERICAN BUSINESS AWARDS®

PrestigePEO

PrestigePEO, one of the nation’s largest professional employer organizations (PEO), announced today it was named winner of two Bronze Stevie® Awards in both the Company of the Year - Business & Professional Services – Medium and Achievement in Sales or Revenue Generation categories of The 22nd Annual American Business Awards®. The American Business Awards are the U.S.A.’s premier business awards program. All organizations operating in the U.S.A. are eligible to submit nominations – public and private, for-profit and non-profit, large and small. Nicknamed the Stevies for the Greek word meaning “crowned,” the awards will be presented to winners at a gala ceremony at the Marriott Marquis Hotel in New York on Tuesday, June 11. Tickets are now on sale. PrestigePEO was recognized in this prestigious competition for its distinctive model and service offering to small and medium-sized businesses (SMBs) as well as its commitment to customer service, market expansion, and introduction of innovative solutions. As a PEO, PrestigePEO supports SMBs nationwide by providing an extensive menu of human resources and administrative services to expand their employee benefits offerings and provide their HR operations with deep guidance and expertise. “This recognition is a tribute to PrestigePEO’s team. They work tirelessly every day to ensure our clients and their employees receive exceptional service and a broad portfolio of best-in-class benefits options. Our distinctive service model is dedicated to the delivery of top-notch service, which is the primary reason why PrestigePEO was recognized by the Stevie Awards program,” commented PrestigePEO’s Chief Operating Officer Robyn Rusignuolo. “From our humble roots as an entrepreneurial start-up organization in 1998, PrestigePEO has since morphed into one of the nation’s top PEOs. We earned this ranking not only from our ever-increasing menu of benefits and services but also because of the people we employ, the diverse companies we serve, and our unrelenting efforts to continually expand our offerings. We thank the judges for recognizing our company and team,” said PrestigePEO Chief Executive Officer Andrew Lubash. An excess of 3,700 nominations from organizations of all sizes and in virtually every industry were submitted this year for consideration in a wide range of categories. More than 300 professionals worldwide participated in the judging process to select this year’s Stevie Award winners. Details about The American Business Awards and the list of 2024 Stevie winners are available at www.StevieAwards.com/ABA. About the Stevie Awards Stevie Awards are conferred in nine programs: the Asia-Pacific Stevie Awards, the German Stevie Awards, the Middle East & North Africa Stevie Awards, The American Business Awards®, The International Business Awards®, the Stevie Awards for Women in Business, the Stevie Awards for Great Employers, the Stevie Awards for Sales & Customer Service, and the new Stevie Awards for Technology Excellence. Stevie Awards competitions receive more than 12,000 entries each year from organizations in more than 70 nations. Honoring organizations of all types and sizes and the people behind them, the Stevies recognize outstanding performances in the workplace worldwide. Learn more about the Stevie Awards at http://www.StevieAwards.com. About PrestigePEO Melville, N.Y.-based PrestigePEO, also known as Prestige Employee Administrators LLC, provides integrated, end-to-end outsourced solutions to small and medium-sized businesses (SMBs) for managing all integral benefits and human resources operations. This includes support for employee benefits management, payroll administration, workers’ compensation, compliance, and HR guidance, among other areas. PrestigePEO’s full spectrum of solutions helps SMBs lower employee benefit costs, reduce administrative workloads, and manage critical HR functions. PrestigePEO is among only 1% of PEOs accredited by the Employer Services Assurance Corporation (ESAC), certified (CI) through Workers Comp Risk Management and classified as a Certified Professional Employer Organization (CPEO) by the IRS – demonstrating financial stability and strict adherence with a diverse range of regulatory and security standards. To learn more, visit www.prestigepeo.com and follow PrestigePEO on Facebook, Twitter, LinkedIn and YouTube. Contact Details PAIRELATIONS, LLC Susan Turkell +1 303-766-4343 sturkell@pairelations.com Company Website https://www.prestigepeo.com/

May 08, 2024 08:00 AM Eastern Daylight Time

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