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How Theriva Biologics Is Using An Adenovirus To Develop A Novel Treatment For Pancreatic Cancer, As Well As Other Cancers With An Unmet Need

Benzinga

By Faith Ashmore, Benzinga Pancreatic cancer has, unfortunately, been in the news lately due to the rising rates of early-onset cancer, especially in young people. The gastrointestinal cancer, which has a 12% five-year survival rate, is expected to become the second-highest cause of cancer-associated deaths in 2030 in the U.S. In 2024, it is projected that 64,440 Americans will be diagnosed with pancreatic cancer. The global market size for pancreatic cancer was valued at $2.22 billion in 2022, and it is expected to be worth around $7.91 billion by 2032. Despite the multi-billion dollar market size, the industry is expected to grow at 13.6% through 2032, and pancreatic cancer still needs more therapeutic options – especially for advanced cases or when existing treatments don’t yield the desired results. Theriva Biologics (AMEX: TOVX) is a biotech company that is looking to use adenoviruses to help treat pancreatic cancer. Adenoviruses are a class of viruses with an established safety profile. They are highly prevalent in the environment, making them ideal candidates for therapeutic use in the cancer field. Theriva Biologics' lead product candidate, VCN-01, is a uniquely modified human adenovirus designed for systemic delivery to treat different types of cancer. Theriva Biologics reports that phase 1 clinical trials of VCN-01 have shown promising results for the treatment of several additional indications apart from pancreatic cancer, such as retinoblastoma, head and neck squamous cell carcinoma (HNSCC) and colorectal cancer (CRC) in combination with chemotherapy and immunotherapies. Currently, the company is conducting a phase 2b clinical trial of VCN-01 in combination with standard-of-care chemotherapy for first-line metastatic pancreatic cancer. It is on track to complete enrollment into the VIRAGE Study by the first half of 2024. In the first quarter of 2024, a Drug Monitoring Committee (DMC) conducted a thorough safety review of VCN-01, and found that the VCN-01 safety profile permitted the VIRAGE study to continue without modification. By the second half of 2024, Theriva Biologics aims to perform an interim analysis of the data obtained from the VIRAGE Study. Pancreatic cancer presents several unique challenges that contribute to its high mortality rate and the difficulty in managing the disease. One major challenge is the aggressive nature of pancreatic cancer, which often spreads to other organs before being diagnosed. Approximately 50% of patients are diagnosed when the cancer has already metastasized, resulting in advanced-stage disease. Pancreatic cancer is also known for causing nonspecific symptoms, making it challenging to detect in its early stages. VCN-01 has a systemic delivery approach, which means it can target both the main tumor and distant metastases, which makes it a promising therapeutic option for advanced and difficult-to-treat cancers like pancreatic cancer. If the company can successfully harness the benefits of adenoviruses, it will present suffering patients around the globe with a novel solution to extend their lives. Featured photo by Olga Kononenko on Unsplash Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

March 14, 2024 08:20 AM Eastern Daylight Time

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Tirupati Graphite advances graphite exploration in Madagascar amid global demand surge

Tirupati Graphite PLC

Tirupati Graphite PLC (LSE:TGR, OTCQX:TGRHF) joint managing director Puruvi Poddar joins Proactive's Stephen Gunnion with details of an exploration programme at the company's flake graphite projects in Madagascar. The programme, differing from prior approaches, involved over 5,000 diamond core drill cores and more than 25,000 auger drills. SRK Consulting has visited the site to compile data for an updated Competent Persons Report (CPR), marking continuous exploration efforts over the last three years. Poddar also touched on the global graphite market, highlighting the restrictions on graphite exports from China. These restrictions have intensified demand for graphite worldwide, underscoring its importance as a critical material. She said Tirupati Graphite is uniquely positioned as one of the few significant graphite producers outside China, with operations in Mozambique and Madagascar. This strategic position is poised to benefit from the growing demand for graphite, especially from the battery sector, with anticipated increases in graphite prices and demand. Despite challenges, including a working capital gap partly due to delayed funds from the Madagascan government, the company remains optimistic about its ability to meet future demand and achieve its immediate goal of becoming EBITDA positive. Poddar said Tirupati Graphite's capacity to produce 1,500 to 1,600 tonnes of graphite per month and established market presence underscore its potential in the rapidly evolving graphite market. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

March 14, 2024 08:19 AM Eastern Daylight Time

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Great Southern Copper reveals promising drilling results at Teresita and Abundante prospects

Great Southern Copper PLC

Great Southern Copper PLC (LSE:GSCU) chief executive Sam Garrett discusses early results from the company's RC drilling programmes at the Teresita and Abundante prospects, highlighting their significance and the confirmation of the geological model being pursued. In an interview with Proactive's Stephen Gunnion, Garrett noted the drilling results at Teresita have revealed large quartz sulphide carbonate veins with cumulative strike lengths of approximately five kilometres, carrying high-grade gold and copper. A particular drill hole, hole 10, uncovered a 20-metre-wide vein at shallow depths, showing significantly higher grades than surface outcrops. Garrett said the results also give the company confidence in the way forward and how to approach the ongoing exploration at Teresita and Abundante. Future exploration will utilise detailed soil sampling and geophysical techniques to better target drill holes. Garrett said the success at Teresita, along with similar findings at the Victoria prospect, suggests the presence of large-scale, high-grade copper and gold systems, bolstering confidence in the project's potential. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

March 14, 2024 08:18 AM Eastern Daylight Time

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Atrato Capital highlights strong performance and growth opportunities for Supermarket Income REIT

Supermarket Income REIT PLC

Atrato Capital managing director, Robert Abraham and finance director Michael Perkins visit the Proactive studio to discuss the interim results of Supermarket Income REIT PLC (LSE:SUPR, OTC:SUPIF), emphasising the sector's strong performance. Abraham said key tenants, Tesco and Sainsbury's, have reported robust sales growth and market share, particularly in omni-channel stores, which have seen the most significant sales increases. The investment market presents an attractive pipeline of accretive assets for SUPR, with current leverage allowing capacity for targeting these opportunities, he added. Perkins noted that SUPR reported a 15% increase in net rental income for the six months ending December 2023, driven by acquisitions and rent review income, maintaining stable adjusted earnings of 2.9 pence. Despite operating at lower leverage, the company is on track to meet its full-year dividend target of 6.06 pence. Since SUPR's IPO in 2017, Abraham said the grocery sector has seen a 35% sales growth, reaching a market size of £250 billion, with this increase largely attributable to like-for-like sales growth in omni-channel spaces, indicating a maturation phase for discounters. The grocery sector's strength has enhanced the property market, with store turnovers growing ahead of rents, demonstrating the affordability of rents for key tenants. The investment market has witnessed record volumes of £2.1 billion, highlighting the attractiveness of supermarkets as an investment. With a robust balance sheet, low leverage (LTV of 33%), and significant headroom across banking covenants, Perkins said is well-positioned to pursue earnings-accretive acquisitions. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

March 14, 2024 08:16 AM Eastern Daylight Time

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Meet Atlas Obscura, The Travel Platform That Combines The Wonder Of Ripley’s Believe It Or Not With The Breadth Of National Geographic’s Content

OurCrowd

By Meg Flippin, Benzinga Combining the wonderment and obscurity of “Ripley’s Believe It or Not” with the high-quality production of National Geographic, Atlas Obscura is changing the way we travel and consume travel-related content. The U.S.-based travel media company, which counts millions of consumers as customers, is making a name for itself in the travel industry, creating and curating unique travel experiences whether in person, online or in print. You may not find a run-of-the-mill cruise to Mexico when you peruse this startup’s offerings, but you will find a tasting trip to Oaxaca where you can sample the culinary delights and soak up the culture of this bustling city. Don’t feel like leaving your home for a unique experience? With a click of the mouse, you can be part of a virtual tour of the Bone Museum in Brooklyn or hear a three-part lecture on the history of space exploration. Curating Content And Experiences For Travelers The company holds appeal for travel enthusiasts looking for unique experiences online and in person and for once-in-a-lifetime trips. It leverages the Atlas, its community-driven platform to provide travelers with access to over 25,000 wondrous places around the world. Unlike other leading travel media companies, Atlas is a collaborative project that depends on its community of explorers to help discover amazing places and share them with the world. In addition to offering over 137 unique international destinations and boasting a global community of 10 million explorers, Atlas Obscura reports that it operates the no. 1 travel podcast on Apple charts, published three consecutive New York Times bestsellers with more in the works and recently became one of six exclusive partners for Delta Airlines Inc.’s (NYSE: DAL) billion-dollar inflight entertainment hub Delta Sync Exclusives, sharing the deal with such heavy-hitters as T-Mobile US Inc. (NASDAQ: TMUS), Paramount+, American Express Co. (NYSE: AXP), Resy and the New York Times Games. Through the deal Atlas Obscura will reach millions of flyers annually, providing them insider tips and destination information. The company already counts BrandUSA, Puerto Rico, Florida, Texas and Los Angeles as partners and creates content for some of the world’s largest brands including Land Rover, Nissan Motor Co. (OTCMKTS: NSANY), Netflix Inc. (NASDAQ: NFLX) and JPMorgan Chase & Co. (NYSE: JPM). Out-Of-The-Box Travel In Demand What started more than a decade ago as a two-person passion project of Joshua Foer and Dylan Thuras to map the hidden wonders of the world has morphed into a media powerhouse with 6.5 million monthly active users, 3 million social media followers, 1.6 million monthly podcast downloads and 1.5 million email subscribers. To help Atlas Obscura grow even more in the travel industry click here. Investors Taking Notice That growth hasn’t been lost on investors either. John Backus, founder and managing director of PROOF.VC – an expansion-stage venture capital firm that invests in rapid-growth, breakout companies across the venture ecosystem – is an early backer of Atlas Obscura and is taking part in the company’s most recent Series A round on OurCrowd in which it's seeking to raise $10 million. “We love this company. It’s at scale. It’s about $20 million in revenue, and it’s been profitable for the last year,” Backus, who sits on the board, recently said. “This is a company that is profitable, that is growing, that is looking to invest in its media business and create content that can last in perpetuity.” Since the second quarter of 2023, the company has been profitable. Atlas Obscura’s popularity is driven by the fact that it's solving a common problem in the travel industry: a lack of cool places to visit. The world is vast and interesting with more and more travelers across all ages and demographics looking for unique vacations, yet finding them on traditional travel websites and apps can be difficult and time-consuming. When planning a trip, individuals on average search 40 travel websites. Meanwhile, visitor bureaus tasked with promoting tourism for their city, state or country are looking for ways to build their brands and provide better experiences for visitors. All of that plays to Atlas Obscura’s strengths. Nor is the company sitting back and enjoying its success. It plans to leverage its database of unique destinations by developing an AI tool that will create personalized travel itineraries in minutes. It’s betting that will not only accelerate growth but improve the user travel planning experience. Interested in investing in a company transforming the way we travel? Click here to learn how. Featured photo by Ian Schneider on Unsplash. OurCrowd was started in 2013, driven by the idea that the business of building startups grows bigger and better when the global ‘crowd’ gains access to VC-level investment opportunities.Today, OurCrowd is a global venture and alternative investing platform that empowers institutions and individuals to invest and engage in emerging companies. OurCrowd vets and selects companies, invests its capital, and provides its global network with unparalleled access to co-invest and contribute connections, talent and deal flow. OurCrowd builds value for its portfolio companies throughout their lifecycles, providing mentorship, recruiting industry advisors, navigating follow-on rounds and creating growth opportunities through its network of multinational partnerships. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Lisa Graston lisa.graston@ourcrowd.com Company Website http://www.ourcrowd.com

March 14, 2024 08:15 AM Eastern Daylight Time

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Arecor Therapeutics announces collaboration on oral GLP-1 drug for diabetes and obesity treatment

Arecor Therapeutics PLC

Arecor Therapeutics PLC (AIM:AREC) CEO Sarah Howell joined Proactive's Stephen Gunnion with details of a collaboration with TRX Biosciences to develop an oral GLP-1 product for treating type 2 diabetes and obesity. GLP-1s are therapeutic peptides known for improving blood sugar levels and promoting weight loss. The market for GLP-1 products is expected to reach $100 billion by 2030. Currently, GLP-1 treatment options are predominantly injectable, which limits patient compliance and adoption. Arecor aims to develop an oral GLP-1 with enhanced bioavailability, making it a once-daily pill. This development could significantly increase access to effective treatments for these conditions. Howell told Proactive that Arecor is well-positioned for this development due to its successful track record with its Arestat technology platform, which enhances the profiles of existing therapeutics. The collaboration aims to overcome challenges faced by the only available oral GLP-1, such as low bioavailability and the need for dosing on an empty stomach, by leveraging Arecor's technology in conjunction with TRX Biosciences' Lipper core technology. She said the collaboration complements Arecor's existing diabetes portfolio, which includes two leading insulin products and Gluco, a product for severe hypoglycemia in diabetes patients. The focus is on reducing the daily burden of disease management and improving patient outcomes. TRX Biosciences was chosen for their complementary technology and expertise in oral peptide delivery. The initial development phase will last up to 18 months, aiming to demonstrate the feasibility of a stable, orally delivered GLP-1 with improved bioavailability. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

March 14, 2024 08:13 AM Eastern Daylight Time

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Bradda Head Lithium targets resources expansion as drilling kicks off at Basin project in Arizona

Bradda Head Lithium Limited

Bradda Head Lithium Limited (AIM:BHL, OTCQB:BHLIF, TSX-V:BHLI) executive chairman Ian Stalker joins Proactive's Stephen Gunnion with news that drilling has commenced at the Basin Project in Arizona, aimed at expanding the lithium resources. Stalker said the company, optimistic about the lithium market's upward trend, is leveraging this timing to potentially grow the inferred resource from one million tonnes to two and a half million tonnes within six weeks. This expansion is critical as it could unlock $3 million US dollars from a previous agreement with Lithium Royalty Company, enhancing the company's financial position. Bradda Head's 2023 sonic drilling campaign has bolstered this confidence, with consistent mineralization findings and no failures in their drilling efforts. Looking ahead, the company may consider further drilling or focus on its San Domingo hardrock pegmatite project, depending on the outcomes and the lithium market's status. Additionally, Bradda Head has reached a settlement with Arizona Lithium, securing additional claims for its Wikieup clay project, which is seen as an opportunity to extend the lithium resources. Beyond these projects, Bradda Head is eyeing potential in lithium extraction from brines, particularly in areas previously explored by major oil companies for oil and gas. This diverse project portfolio positions Bradda Head to capitalize on the anticipated positive shift in the lithium market. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

March 14, 2024 08:10 AM Eastern Daylight Time

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News Release

Bitget Lists Brett (BRETT) to Introduce New Cultural Icon in DeFi Space

Bitget

Bitget, the leading cryptocurrency exchange and Web3 company, is thrilled to announce the addition of Brett (BRETT) to its trading platform. The introduction of Brett token brings forth a legendary character inspired by Matt Furie's comic creation, Boy's Club, reminiscent of the iconic Pepe character. Brett emerges as a symbol of creativity and innovation within the decentralized finance (DeFi) realm, drawing inspiration from popular culture icons. This unique presence has captivated a global audience, resonating with fans who admire Brett's laid-back demeanor and passion for video games. As one of crypto's most significant cultural icons, Brett stands tall as the esteemed mascot of BASE chain. Gracy Chen, Managing Director of Bitget, stated, "Bitget seeks a meaningful way to champion the development of various blockchains and ecosystems. This project exemplifies innovative potential and underscores our dedication to supporting the crypto ecosystem, providing our users with access to cutting-edge projects. Our vision is to foster a Spot Market enriched with diverse choices and top-quality projects." Bitget has consistently expanded its market share in both spot and derivatives trading among centralized exchanges. With a focus on providing users with opportunities to invest in popular and valuable projects, Bitget's spot market has seen significant growth. In 2023 alone, the platform added over 350 new listings, further diversifying investment options for users. Meanwhile, Bitget Wallet supports over 100 mainnets and 250,000+ tokens. Its on-chain trading function Bitget Swap enables cross-chain trading between nearly 30 mainnets. About Bitget Established in 2018, Bitget is the world's leading cryptocurrency exchange and Web3 company. Serving over 25 million users in 100+ countries and regions, the Bitget exchange is committed to helping users trade smarter with its pioneering copy trading feature and other trading solutions. Formerly known as BitKeep, Bitget Wallet is a world-class multi-chain crypto wallet that offers an array of comprehensive Web3 solutions and features including wallet functionality, swap, NFT Marketplace, DApp browser, and more. Bitget inspires individuals to embrace crypto through collaborations with credible partners, including legendary Argentinian footballer Lionel Messi and official eSports events organizer PGL. For more information, visit: Website | Twitter | Telegram | LinkedIn | Discord | Bitget Wallet Contact Details Bitget Rachel Cheung media@bitget.com Company Website https://www.bitget.com/

March 14, 2024 07:57 AM Eastern Daylight Time

CleanCloud Celebrates Major Growth Milestones As Business Enters 10th Year

CleanCloud

CleanCloud, the industry-leading software provider for laundromats and dry cleaners, today announced a series of remarkable milestones that highlights its continued growth as it enters into its 10th year. Setting unprecedented standards in the laundry industry's digital transformation, these achievements reinforce CleanCloud’s position as the partner of choice for modern laundromats. More than 10 million customers reached through its innovative software Over $1 billion processed in transactions Since its founding in 2014, CleanCloud has been dedicated to helping laundromats and dry cleaners grow their business through its innovative software solutions. The announcement of these latest business milestones underscore the company's success in providing powerful, user-friendly tools that help laundry businesses digitize their orders, streamline their operations and run their businesses more efficiently. A Commitment To Industry Excellence These numbers reflect CleanCloud’s ongoing commitment to providing excellent service, and its ability to continue to meet the evolving needs of modern laundry businesses. CleanCloud has built its reputation on providing a reliable, trustworthy service that offers scalability alongside a comprehensive feature set. This combination has made them an essential option for growth minded laundry businesses looking to capitalize on the growing demand for convenient and efficient laundry services. The latest achievements announced by the company are more than just numbers, they’re a true testament to the impact that CleanCloud has made on the industry: Over 10 million customers worldwide have benefited from the convenience and efficiency of CleanCloud-powered services, in-store and online through pick up and delivery services and customer apps, demonstrating the widespread trust in its technology. Transactions surpassing $1 billion through its software represent the opportunity that exists in the industry, as online orders and digital payments continue to grow in popularity, CleanCloud are uniquely positioned to help laundry businesses succeed. Customer Success at the Heart of Operations "CleanCloud's mission from the start has been to empower laundry businesses with the tools they need to succeed in a digital-first world," said CleanCloud's Co-Founder and CEO, John Buni. "For us, these important milestones are not just numbers; they represent the trust, hard work, and entrepreneurial spirit of our customers. We're proud to be part of their journey and are excited about the future as we continue to support their growth and success." About CleanCloud CleanCloud is at the forefront of the digital transformation in the laundromat and dry cleaning industry, offering a suite of advanced software solutions designed to streamline operations, enhance customer experiences, and grow revenues. With a focus on innovation, reliability, and customer support, CleanCloud continues to lead the way in helping laundry businesses worldwide achieve their ambitions. Contact Details CleanCloud Leanne Patterson leanne@cleancloud.com

March 14, 2024 03:00 AM Eastern Daylight Time

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