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Revolutionizing gastroparesis treatment: Evoke Pharma's CEO talks game-changing nasal spray

Evoke Pharma

Evoke Pharma CEO Dave Gonyer joined Steve Darling from Proactive to share news the company has achieved a significant milestone with the listing of its recently issued U.S. patent related to GIMOTI in the U.S. Food and Drug Administration's publication, commonly known as the "Orange Book." This development is of great importance as patents listed in the Orange Book cover drugs that the FDA has approved and deemed safe and effective for public use. The patent, titled "Nasal Formulations of Metoclopramide," pertains to a collection of nasal solutions of metoclopramide and outlines its characteristics when formulated. This newly listed patent in the FDA's Orange Book carries a patent term extending until 2029. Its inclusion adds an additional layer of patent protection for GIMOTI, complementing the three prior patents listed. This achievement underscores Evoke Pharma's commitment to advancing its innovative metoclopramide nasal spray, GIMOTI, which is designed to provide a treatment option for patients suffering from gastroparesis. The FDA's recognition of the patent's significance reaffirms GIMOTI's potential to address the unmet medical needs of patients. Furthermore, Gonyer shared insights into the company's recent financial performance, reporting a remarkable 38% increase compared to Q2 2023 and an impressive 88% increase year-over-year in Q3. These positive financial results set the stage for Evoke Pharma's ambitious growth plans for 2024. As Evoke Pharma continues to make strides in the pharmaceutical industry, its commitment to innovation, patient care, and expanding its patent portfolio positions the company for further success in the years ahead. Investors and stakeholders can look forward to the company's continued growth and contributions to improving patient outcomes. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

November 30, 2023 12:16 PM Eastern Standard Time

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Sui Surpasses $150M in TVL, Showcasing Blistering DeFi Momentum

Sui

Sui, the pioneering Layer 1 blockchain and smart contract platform created by the technology team that emerged from Meta’s Diem Blockchain project, has accelerated beyond expectations in just over six months since its mainnet launch, surpassing $150 million in Total Value Locked (TVL) according to leading DeFi aggregator DefiLlama. This key milestone, which currently places Sui within the top 20 blockchains in TVL, signifies a growing DeFi ecosystem backed by a deep pool of developer talent and a community that is strengthening by the day. In addition to its TVL trajectory, which is up over 500% since the start of September, the Sui Network has surged past $100 million in bridged stablecoins. Sui has also surpassed Bitcoin in total historical on-chain transaction count, affirming its capacity for scalability and efficiency, and underscoring the blockchain’s ability to facilitate seamless, secure, and lightning-fast transactions. The ability to process a high volume of transactions while maintaining peak network performance has supported this DeFi growth, as Sui recently set a new record for the most transactions processed in a single day by any blockchain ever. “Sui’s rapid ascension reflects both the growing demand for its unique, native technology and a vibrant community that is fueling the growth and adoption of the Sui Network,” said Greg Siourounis, Managing Director of the Sui Foundation. “To reach this level of adoption within months of the network’s mainnet launch is remarkable and bodes extremely well for the future of this burgeoning DeFi ecosystem.” This level of growth is further supported by a robust network of independent DeFi projects adding value and utility for the community. For example, Cetus, a leading DEX and concentrated liquidity protocol within the Sui ecosystem, also recently achieved a significant feat by surpassing $1 billion in total transaction volume. This accomplishment underscores the depth and decentralization of the Sui Network’s DeFi landscape. Builders on Sui are also prioritizing relationships and collaborations across the globe, as evidenced by the recent partnership announcement with technology incubator Hub71. With roots in Abu Dhabi, the UAE’s capital, and a large investment base, Hub71 supports over 260 startups, and has committed to introducing UAE-based startups to the Sui ecosystem. Sui’s ascendancy makes it a growing force in the industry as Web3 braces itself for what many expect to be a period of high growth. With its object-centric model and unparalleled scalability, Sui’s potential for mass adoption arises from its simplicity for developers and rapid transaction processing for broader use cases. Builders, users, and organizations alike can learn more about the network by visiting https://sui.io. Contact Details Sui Foundation Sui Team media@sui.io

November 30, 2023 12:08 PM Eastern Standard Time

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Shiba Inu and Dogecoin Two Meme-Coins Positioned for Growth, Everlodge to Dominate $4.548B Real Estate Market

Total Media

Shiba Inu (SHIB) is primed for a bullish run based on data from its TD Sequential setup, as highlighted by a top crypto market analyst. Dogecoin (DOGE) is also showcasing bullish momentum after Coin98 announced that it would integrate the crypto through the Super Wallet user-friendly interface, which can result in a spike in its activity. Everlodge (ELDG) will soon enter the global hospitality industry worth over $4.548 billion and, as a result, will be a favorite among whales. Summary Shiba Inu prepared to grow to $0.000012 in Q1, 2024 Dogecoin to reach $0.1290 in the next year Everlodge can spike 27x following its listing on major CEXs Shiba Inu (SHIB) Projected to Surge by Ali Martinez Shiba Inu (SHIB) recently saw an upswing in activity, and according to top crypto analyst Ali Martinez, it will soon see another mega run based on its key technical setup. Martinez said that this is based on the TD Sequential indicator; Shiba Inu showcased a buy signal on the weekly chart. During the past week, the SHIB crypto moved in value from a low point of $0.00000780 to a maximum point of value of $0.00000851. With a market cap of $4,816,353,432, it's the 20th largest, and according to the Shiba Inu price prediction, it can spike to $0.000012 by Q1, 2024. Dogecoin (DOGE) to See an Upswing to $0.1290 Dogecoin (DOGE) recently crossed the five million addresses count that have a balance and are holding the crypto based on data from IntoTheBlock. The Dogecoin crypto was also boosted by the announcement of the DeFi platform Coin98 on the integration of the crypto onto their latest version of the Coin98 Supper Wallet and Coin98 Extension, delivering numerous advantages to the holders of the crypto. DOGE moved up in value from a low point of $0.072259 to a high point of $0.081126. Based on the Dogecoin price prediction, it can spike as high as $0.1290 by Q1 2024. Everlodge (ELDG) to Dominate the $4.548 Billion Market While Shiba Inu and Dogecoin are bullish, Everlodge can soon dominate the industry. This is an upcoming project that will enter the global hospitality industry worth over $4.548 billion and, as a result, is appealing to thousands of traders globally. The platform will also solve key issues plaguing the industry for years. Traditionally, getting access to a property can cost millions of dollars. Yet many people want to acquire these properties, and Everlodge will make this possible for as little as $100. The platform will mint each property as an NFT. Then, it will fractionalize these properties into thousands of smaller parts. This way, anyone can diversify with ease, starting at $100. There is even a Rewards Club, where users can access free nightly stays at specific locations and even resell them for additional capital gains. The ELDG crypto is used for staking and for governance. At stage seven, it is trading at a value of $0.025 but can spike by 27x based on the latest projections. Visit Everlodge Contact Details Everlodge Media media@everlodge.io

November 30, 2023 12:00 PM Eastern Standard Time

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Ionic Rare Earths in final stages of mining licence approval

Ionic Rare Earths Ltd

Ionic Rare Earths Ltd (ASX:IXR, OTC:IXRRF) MD Tim Harrison tells Proactive the company has made further progress in securing land access agreements for the Makuutu Rare Earths Project in Uganda, while the verification process has been completed for the Mining Licence Application (MLA) for stage one of the project’s development. The Makuutu heavy rare earths project has the government’s full support and is set to become Uganda’s flagship mine. The project contains 71% magnet and heavy rare earths, and is one of the most advanced heavy rare earth projects globally available as a source for new supply chains emerging across Europe, the US and Asia. The company says that the final administrative stages of the mining licence approval process are underway. Makuutu’s basket contains 71% magnet and heavy rare earths content, and is one of the most advanced heavy rare earth projects globally available as a source for new supply chains emerging across Europe, the US, and Asia. Contact Details Proactive Investors Jonathan Jackson +61 413 713 744 jonathan@proactiveinvestors.com

November 30, 2023 11:45 AM Eastern Standard Time

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Giyani Metals secures $26 million funding boost; CEO reveals exciting plans for 2024

Giyani Metals Corp

Giyani Metals CEO Danny Keating joined Steve Darling from Proactive to reveal an exciting development for the company with the acquisition of a $26 million financing package. This funding includes a substantial $16 million injection from South Africa's Industrial Development Corporation (IDC), which will serve as a catalyst for Giyani Metals' strategic plans in 2024. Keating underscored the growing significance of high-purity manganese in the electric vehicle (EV) battery sector. The company has made substantial progress in expanding its resource base and establishing robust project economics. With its resources tripling, a net present value (NPV) exceeding $1 billion, and an internal rate of return (IRR) of 29%, Giyani Metals Corp is well-positioned to play a pivotal role in the battery supply chain. Keating also highlighted the importance of Giyani's demonstration plant in Johannesburg, which exemplifies their commitment to delivering a high-specification manganese product. The new financing provides the company with the means to address technical challenges, secure offtake agreements, and advance its projects. As Giyani Metals Corp enters 2024, the company anticipates a dynamic year marked by significant progress. The financing package and partnership with the Industrial Development Corporation further validate the company's path towards project financing and its credibility as a key player in the high-purity manganese market. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

November 30, 2023 10:53 AM Eastern Standard Time

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Tech the Halls

News Media Group, Inc.

Contact Details News Media Group, Inc. Karl Wayne +1 334-440-6397 karl@newsmg.com Company Website https://newsmg.com/

November 30, 2023 10:51 AM Eastern Standard Time

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Cyclone Metals produces class-leading iron ore product

Cyclone Metals Ltd

Cyclone Metals Ltd (ASX:CLE) CEO Paul Berend tells Proactive the company has produced a class-leading iron ore product with metallurgical test work on ore from the flagship Block 103/Iron Bear Magnetite Project in Canada, achieving a blast furnace concentrate of 68.7% iron with low impurities and silica content below 3.5%. The company achieved high recoveries of more than 97% from a sediment bulk sample of 1.6 tonnes containing 17% iron, a good representative of the overall deposit, which on average contains 18% iron. Berend said: “We are working hard to define a premium ultra-low silica direct reduction magnetite product which will be very attractive to European steel makers looking to reduce their carbon footprint. “We are targeting to introduce this unique premium product to the steel industry as early as the first quarter of next year.” Contact Details Proactive Investors Jonathan Jackson +61 413 713 744 jonathan@proactiveinvestors.com

November 30, 2023 10:30 AM Eastern Standard Time

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AeroBase Group Most Admired Companies of the Year 2023

500NewsWire

ST AUGUSTINE, FLORIDA, UNITED STATES, Nov. 30, 2023 - ( 500NewsWire ) -- The Silicon Review -- AeroBase Group is a global aerospace and defense supplier, catering to the demands of the fast-paced international markets. It offers a comprehensive range of services including logistics, maintenance, repair, operations, parts distribution, and more. AeroBase sets itself apart with its extensive global footprint, showcasing an innovative approach that offers unmatched support to contractors, manufacturers, brokers, and government agencies around the world. Currently, the company is active in 100 countries. AeroBase utilizes its in-house software to facilitate efficient sourcing and procurement of the necessary parts for diverse aircraft requirements. The company’s product portfolio encompasses aircraft, maritime, and locomotive parts, along with mil-spec hardware, medical supplies, and ground support equipment. Offering a wide array of options, AeroBase supplies aftermarket, original equipment manufacturer (OEM) parts, government excess surplus, and parts manufacturer approval (PMA) parts. Furthermore, acting as a manufacturing representative, AeroBase not only functions as a licensed distributor but also spearheads marketing endeavors for its manufacturing partners. Irrespective of the requirements, AeroBase is dedicated to providing swift solutions and innovative approaches, ensuring the success of its client base. “We are committed to providing customers the experience, technology and service necessary to operate their business safely and profitably,” said Alexina Cyr, Director (Sales) of AeroBase Group, Inc. In the aerospace and defense sector, customers often grapple with the persistent challenge of maintaining aging legacy platforms. These challenges stem from the obsolescence of particular parts, rendering the sourcing of crucial parts an intricate task. In response, AeroBase has played a pivotal role in helping customers by providing critical parts vital to the smooth functioning of these platforms, including the P-3 Orion, C-130 Hercules, and CH-47 Chinook. “For international customers, we have implemented various languages on our websites to facilitate access to services ( https://aerobasegroup.com/locality /). Additionally, efforts are underway to broaden the product inventory and service offerings on the e-commerce platform, ensuring that international customers can place orders conveniently,” she said. Comprehensive inventory Stock & Distribution: AeroBase has partnerships with OEMs that allow it to stock and distribute new products to its customers. The company also purchases surplus inventory to stock and sell to help support legacy platforms. E-Commerce: AeroBase offers many of its popular products online at https://aerobase.store/. This allows customers to look through products at their leisure and get information such as pricing and availability instantly, simplifying the procurement process on their end. Consignment: AeroBase partners with suppliers to sell their inventory on their behalf so it can provide a wider range of products to its customers. “We are actively enhancing our e-commerce platform to facilitate a more convenient and seamless ordering experience for our customers. Moreover, we are expanding our stock levels to ensure swift availability of products, mitigating the extended lead times that have become prevalent in the industry since the onset of the Covid-19 pandemic,” said Tom Corrao, CEO of AeroBase Group Inc. Primary impetus propelling AeroBase Group As a prominent global defense supplier, AeroBase Group dedicates significant attention to compliance and security, given its involvement in numerous exports. In this regard, the company has implemented an internal export compliance program and is registered with the DDTC to ensure strict adherence to all pertinent export regulations when shipping its products internationally. Furthermore, AeroBase’s team consists of top-tier professionals, recognized for their expertise and unwavering dedication. Renowned for their swift and efficient service, customers highly appreciate the team’s responsiveness and their willingness to exceed expectations. “As a small, minority, woman-owned business with an AS9120-certified quality management system, we are committed to excellence,” said Alexina. Evolution AeroBase Group is a minority woman-owned small business that made a considerable impact on the industry. Tom and his wife started AeroBase with just $3,000 and a passion for innovation. They are a team of visionaries who founded AeroBase Group from their humble guest bedroom in August 2013. Having worked with several aircraft parts distributors before, they saw some things the industry could do differently. “For one, they sought to use cutting edge technology to streamline the process of securing parts for aerospace and defense. Our tools and software were designed to minimize companies’ time researching, negotiating, and procuring parts,” said Alexina. With an organizational culture that emphasizes passion and a positive outlook rather than conventional sales strategies, AeroBase established itself as an industry frontrunner. In the initial half-year of its operations, the company garnered a customer base exceeding 50,000 unique customers. Needless to say, with the right tools and a passionate team, AeroBase Group provides customers with the experience, technology, and service to succeed. Leadership | AeroBase Group Inc. Alexina Cyr, with 10 years of experience, currently holds the position of Director (Sales) at AeroBase Group, Inc. She is an alumna of the University of Florida, possessing a bachelor’s degree in International/Global Studies. Tom Corrao serves as the CEO of AeroBase Group, Inc. AeroBase Group, Inc. Cage Code: 74B05 Duns: 079345899 St. Augustine, Florida Location Administration and fulfillment 3555 Agricultural Center Dr. St. Augustine, FL 32092 Melbourne, Florida Location Account Management and Sales Operation 2910 Bush Dr. Melbourne, FL 32935 Contact Details AeroBase Group, Inc. contact@aerobasegroup.com

November 30, 2023 10:00 AM Eastern Standard Time

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PathAI Launches ArtifactDetect Model on AISight, Pioneering Automated Slide Quality Analysis in Pathology Labs

PathAI

PathAI, a leading digital and computational pathology company which provides precision pathology solutions has announced the availability of ArtifactDetect 1 on AISight ™ 2, PathAI’s digital pathology image management system. This product automates the detection of artifacts on digital pathology whole slide images and quantifies the extent of artifact on any WSI. Artifacts are unintentional morphological features that do not have any histopathological relevance. Artifacts can limit the utility of these images for review by pathologists and require replacement of the image, which can create delays in slide review and case turnaround time. The addition of ArtifactDetect to the menu of algorithms available through AISight broadens the set of efficiencies that are enabled through computational pathology and improved laboratory operations with a digital workflow. This technology automatically identifies poor-quality samples, allowing for timely interventions such as re-staining or re-scanning, thereby saving valuable resources on scanning tech, histotechnology, and pathologist time. This announcement addresses a crucial gap in pathology labs — the lack of a standardized slide quality control system. Pathologists often spend significant time reviewing non-evaluable slides due to the absence of established quality standards. With ArtifactDetect, PathAI aims to provide quality control and workflow optimization features, empowering pathology labs worldwide. “We are very excited to partner with PathAI to enhance automation and accuracy in our laboratories, benefiting both our operations and the value we bring to our beneficiaries,” remarked Dr. Fernando Soares, Full Professor at the University of Sao Paolo and Head of the Department of Anatomic Pathology at Rede D’Or. Rede D’Or is the largest integrated health network in Brazil with more than 70 hospitals and 55 oncology clinics in operation across more than ten states. “We have been testing the AIM-HER2 Breast Algorithm on our diverse cohorts to much success and are excited to expand our collaboration with PathAI to include algorithms that can drive workflow efficiencies and help us better track the quality of our whole slide images.” "The absence of a consistent slide quality standard leads to inefficiencies and challenges in pathology labs," says Dr. Eric Walk, Chief Medical Officer at PathAI. "Our goal is to distribute our advanced algorithms to foster a standardized approach, significantly reducing the time spent on non-evaluable slides." To learn more about AISight, PathAI’s Image Management System, ArtifactDetect or any of PathAI’s other algorithm product solutions, please visit https://www.pathai.com/ap-lab-solutions/ or request a meeting by contacting digitaldx@pathai.com. 1,2 ArtifactDetect and AISight are For Research Use Only. Not for use in diagnostic procedures. About PathAI PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions for clinical trials and laboratory use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. About AISight AISight, introduced earlier this year by PathAI, is a comprehensive digital pathology image management system, currently offered for Research Use Only. AISight provides best-in-class image and case management, ingestion, and viewing while seamlessly enabling access and deployment of AI applications. AISight can also be integrated bidirectionally with laboratory information systems for streamlined workflow adoption. Anatomic pathology laboratories of all sizes and specialties – including health systems, reference laboratories, independent pathology labs, and academic medical centers – may utilize AISight. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

November 30, 2023 10:00 AM Eastern Standard Time

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